The carcinogenicity of 3-methoxy-4-aminoazobenzene and its N-methyl derivatives for extrahepatic tissues of the rat.

The Effect of Dietary Copper on Rat Carcinogenesis by 3-methoxy Dyes. I. Tumors Induced at Various Sites by Feeding 3-methoxy-4-aminoazobenzene and Its N-methyl Derivative.

The carcinogenicity of certain compounds related to p-dimethylaminoazobenzene.

Many aminoazobenzene derivatives have been tested for carcinogenic activity in the rat (1-7). N,N-dimethyl-p-aminoazobenzene and N-methyl-paminoazobenzene have been found to be equally carcinogenic (4, 7). They produced cholangiomas and hepatomas in all animals tested in approximately the same period of time. N,N-dimethyl-3'methyl-4-aminoazobenzene was more carcinogenic than the parent compound...

The carcinogenicity of methoxyl derivatives of 4-aminoazobenzene: correlation between DNA adducts and genotoxicity.

To elucidate the cause of the difference in genotoxic activity between carcinogenic 3-methoxy-4-aminoazobenzene (3-MeO-AAB) and noncarcinogenic 2-methoxy-4-aminoazobenzene (2-MeO-AAB), we analyzed DNA adducts in the livers of rats exposed to either of these chemicals and studied the resulting biologic potential with the aid of in vitro modified M13 phage DNA. 32P-Postalbeling analysis revealed ...

The N-hydroxy metabolites of N-methyl-4-aminoazobenzene and related dyes as proximate carcinogens in the rat and mouse.

The carcinogenicities for rats and mice of N-methyl-4-aminoazobenzene (MAB) and its hepatic microsomal metabolite N-hydroxy-N-methyl-4-aminoazobenzene (N-hydroxy-MAB) were compared under several conditions. N-Ethyl-4-aminoazobenzene, 4-aminoazobenzene, and their N-hydroxy derivatives were also included in some of the assays. About 25% of the rats given MAB or N-hydroxy-MAB (3 to 5 mmol/kg body ...

The carcinogenicity of the o-methoxy derivatives of N-2-fluorenylacetamide and of related compounds in the rat.

In order to test the idea that the lack of carcinogenicity of the o-amidofluorenols, N(1-hydroxy-2-fluorenyl) acetamide and N-(3-hydroxy-2-fluorenyl)acetamide, is due to the hydrophilic phenolic hydroxyl group, the methylated derivatives, N-(1methoxy-2-fluorenyl)acetamide and N-(3-methoxy-2-fluorenyl) acetamide as well as the hydrochlorides of 1-methoxy-2-fluorenamine and 3-methoxy-2-fiuorenami...